Plasma concentrations of flumazenil following intranasal administration in children
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چکیده
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Comparison of misoprostol plasma concentrations following buccal and sublingual administration.
BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...
متن کاملSalivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study.
The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have actually done so. In the present double-blind cross-over study we investigated the longevity of a single 24 IU dose of intranasal OT measured in ...
متن کاملElevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 I...
متن کاملElectrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics
Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough. Design- To determine the heart effects of anesthetics in intranasal administration, an experimental in vivo study was employed. Animals- Ten healthy Choughs were examined in the current study...
متن کاملAccumulation of manganese in rat brain following intranasal administration.
Manganese chloride (50-800 micrograms) was injected unilaterally into the right nostril of rats and its accumulation in the central nervous system (CNS) was monitored. Brain manganese levels were elevated in a dose-dependent, time-dependent, and tissue-dependent manner. Elevated levels of manganese were detected in the right olfactory bulb and olfactory tubercle within 12 hr after instillation ...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2000
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03018846